TUESDAY, Apr 3 (HealthDay News) ? A noninvasive sofa exam could assistance doctors detect early theatre colorectal cancer and precancerous growths, a new investigate says.
The exam competence assistance minimize false-positive formula and forestall deaths compared with this form of cancer, pronounced researchers during a Mayo Clinic in Rochester, Minn., and Exact Sciences, a association building a test.
Still, other issues remain, and experts contend that a stool-based exam won?t reinstate colonoscopy anytime shortly as a best means of spotting colon polyps or tumors.
?For now, colonoscopy stays a undisputed leader when it comes to screening for colon cancer,? pronounced Dr. Lawrence Cohen, associate clinical highbrow of gastroenterology during Mount Sinai School of Medicine in New York City. He was not concerned in a study.
The investigate was to be presented Tuesday during a annual assembly of a American Association for Cancer Research (AACR) in Chicago.
The new stool-based shade targets mixed molecular ?markers? in stool. Tested in 500 patients who were also undergoing colonoscopy or follow-up caring after a showing of colon polyps, researchers found that a shade was rarely supportive to certain vicious early cancer screening targets. Unlike other stool-based colon cancer tests, a new exam also seemed to be unblushing by patients? medications, sex, race, physique mass, lifestyle or family story of colorectal cancer or polyps.
These formula meant that ?patients don?t have to change their lifestyle to have this test,? Dr. David Ahlquist, highbrow of medicine and a consultant in gastroenterology and hepatology during a Mayo Clinic, pronounced in an AACR assembly news release. ?That was critical from a patient-friendly standpoint for a exam like this and could advantage compliance.?
The study?s authors noted, however, that a patient?s age was a one non-static that seemed to change exam results. Based on a study?s findings, a dual markers slightest exposed to age would bear serve exam development.
?This test, if broadly applied, should have a really critical impact on shortening both a mankind and occurrence of colorectal cancer,? Ahlquist said. ?If we can minimize a fake positives, that will revoke a cost of a whole screening module by avoiding nonessential colonoscopies.?
The screening exam is now undergoing FDA validation in a investigate in a United States and Canada. This investigate is approaching to interpretation in a fall.
The Mayo Clinic and Ahlquist reported carrying a financial seductiveness in a screening technology.
Experts in colon cancer impediment pronounced a exam seems to have pros and cons.
?This exam offers poignant intensity to urge on stream stool-based tests as it is unblushing by diet, lifestyle and other critical factors that impact stream stool-based testing,? remarkable Dr. David Bernstein, arch of a multiplication of gastroenterology during North Shore University Hospital in Manhasset, N.Y.
?The need for colonoscopy, however, would be doubtful to change as this exam relies on specific colon cancer gene markers that might not comment for all cases of colon cancer,? he added. ?This exam might be useful in specifying low- from high-risk people during risk for colon cancer.?
For his part, Cohen pronounced a sold gene-based proceed used by a Mayo shade is ?likely to urge a attraction and specificity of this sofa DNA test.? But he pronounced that stool-based screening still falls brief in accurately spotting certain precancerous lesions of a colon compared to colonoscopy.
?An additional plea for sofa contrast is cost,? Cohen added. ?Cost analyses of sofa DNA contrast have found it to be reduction cost-effective than any other process of colorectal screening,? he said.
Research presented during medical meetings is typically deliberate rough until published in a peer-reviewed journal.
More information
The U.S. National Cancer Institute provides some-more information on colon and rectal cancer.
? Mary Elizabeth Dallas
SOURCE: David Bernstein, M.D., chief, multiplication of gastroenterology, North Shore University Hospital, Manhasset, N.Y.; Lawrence B. Cohen, M.D., associate clinical professor, gastroenterology, Mount Sinai School of Medicine, New York City; American Association for Cancer Research, news release, Apr 3, 2012
Last Updated: Apr 03, 2012
Copyright ? 2012 HealthDay. All rights reserved.
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